Friday, November 14, 2008

Genes and the rest of the genome

Scientists studying the human genome, with the help of massively parallel arrays of supercomputers, are uncovering a world of information that is far more complex than anyone dreamed—and far more mysterious: Now - The Rest of the Genome.

...new large-scale studies of DNA are causing her and many of her colleagues to rethink the very nature of genes. They no longer conceive of a typical gene as a single chunk of DNA encoding a single protein. "It cannot work that way," Dr. Prohaska said. There are simply too many exceptions to the conventional rules for genes.

It turns out, for example, that several different proteins may be produced from a single stretch of DNA. Most of the molecules produced from DNA may not even be proteins, but another chemical known as RNA. The familiar double helix of DNA no longer has a monopoly on heredity. Other molecules clinging to DNA can produce striking differences between two organisms with the same genes. And those molecules can be inherited along with DNA.

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